Apport des flavanols du cacao.

Étude en double aveugle sur l’intérêt des flavanols présents dans le cacao sur la fatigue dans la sclérose en plaques.

40 personnes ayant une sep rémittente ont été réparties dans deux groupes :

Un groupe a consommé 1 fois par jour une boisson au cacao très riche en flavanols et l’autre groupe très pauvre en flavanols.

Cette étude montre un léger effet bénéfique sur la fatigue et sur la fatigabilité.

D’autres études sont nécessaires pour pouvoir conseiller une consommation de cacao, lequel, à quelle dose etc. En effet la boisson utilisée ne correspond pas à une consommation correcte de cacao donc inutile de se jeter sur les oeufs…

Article en anglais :

A randomised double-blind placebo-controlled feasibility trial of flavonoid-rich cocoa for fatigue in people with relapsing and remitting multiple sclerosis
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Shelly Coe1, Jo Cossington1, Johnny Collett1, Andrew Soundy2, Hooshang Izadi1, Martin Ovington1, Luke Durkin1, Maja Kirsten1, Miriam Clegg3, Ana Cavey4, Derick T Wade1, Jacqueline Palace2, Gabriele C DeLuca2, Kim Chapman1, Jane-Marie Harrison1, Elizabeth Buckingham1, Helen Dawes1

The impact of flavonoids on fatigue has not been investigated in relapsing and remitting multiple sclerosis (RRMS).

Objective To determine the feasibility and estimate the potential effect of flavonoid-rich cocoa on fatigue and fatigability in RRMS.

Methods A randomised double-blind placebo-controlled feasibility study in people recently diagnosed with RRMS and fatigue, throughout the Thames Valley, UK (ISRCTN69897291). During a 6-week intervention participants consumed a high or low flavonoid cocoa beverage daily. Fatigue and fatigability were measured at three visits (weeks 0, 3 and 6). Feasibility and fidelity were assessed through recruitment and retention, adherence and a process evaluation.

Results 40 people with multiple sclerosis (10 men, 30 women, age 44±10 years) were randomised and allocated to high (n=19) or low (n=21) flavonoid groups and included in analysis. Missing data were <20% and adherence to intervention of allocated individuals was >75%. There was a small effect on fatigue (Neuro-QoL: effect size (ES) 0.04, 95% CI −0.40 to 0.48) and a moderate effect on fatigability (6 min walk test: ES 0.45, 95% CI −0.18 to 1.07). There were seven adverse events (four control, three intervention), only one of which was possibly related and it was resolved.

Conclusion A flavonoid beverage demonstrates the potential to improve fatigue and fatigability in RRMS.

Journal of Neurology, Neurosurgery & Psychiatry 2019; 90 495-495 Published Online First: 04 Mar 2019. doi: 10.1136/jnnp-2018-319926.